Chiral chromatography plays a critical role in the separation and analysis of enantiomers—molecules that are chemically identical but biologically very different. Its importance spans across pharmaceutical development, environmental monitoring, food safety, and forensic analysis.
This technique ensures:
✔ Accurate identification of therapeutically active enantiomers
✔ Removal of harmful or inactive stereoisomers
✔ Improved drug safety and regulatory compliance
Advancements in chiral stationary phases (CSPs), high-performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC), and hyphenated techniques like LC–MS have significantly enhanced resolution, sensitivity, and efficiency.
From understanding historical lessons such as the thalidomide tragedy to adopting green and high-throughput chiral methods, chiral chromatography remains essential in modern analytical workflows.
📌 Full educational video and detailed study notes shared in the link below.
Link to Video: https://youtu.be/lJ9oTZVCW7U
Link to Notes: https://www.doctor-dr.com/2025/12/chiral-chromatography-principles-types.html
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